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Under inflammatory conditions, pro-inflammatory cytokines [e.g., interferon-gamma (IFN-)] can activate IDO1, diverting Trp metabolism toward the kynurenine (KYN) pathway while inhibiting 5-HT synthesis, resulting in serotonin depletion and exacerbation of neurotransmitter imbalance (Rus et al., 2015)

Am J Physiol Endocrinol Metab 2003

It aims to dissect the molecular pathways, evaluate the animal model data, and critically assess the state of human research to equip clinicians with a balanced and actionable perspective

Caffeine Caffeine is a popular and highly consumed food ingredient found in coffee, tea, chocolate, cocoa, some medicines, and dietary supplements (216)

Mousavinejad, E