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Data availability The hippocampi bulk RNA-sequencing data generated in this study have been deposited to the NCBI database under accession code GSE290076

This form may still offer benefits, but efficacy can vary

Even modest resistance exerciseusing body weight, resistance bands, or light weightscan significantly reduce muscle loss during caloric restriction

For comparison, the solubility of control compound 1 previously disclosed in US2013/0324557a1 was also measured