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Nanoscale 8(21):1090810912 Zhan Q, Zhao H, Hong Y, Pu C, Liu Y, Lan M (2019) Preparation of a hydrophilic interaction liquid chromatography material by sequential electrostatic deposition of layers of polyethylenimine and hyaluronic acid for enrichment of glycopeptides

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The principle remains intellectually compelling and mechanistically supported, but clinical demonstration of superiority based on signaling bias alone has yet to be robustly established for most peptide targets