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Reasonable approaches include: Regular blood work every 3-6 months checking metabolic markers, liver function, kidney function, and lipid profiles

Reports of short-term tolerance exist in small observational settings, yet these reports lack randomized control, large populations, and multi-year follow-up

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Int J Mol Sci 15:56495662 Li G, Fu J, Zhao Y, Ji K, Luan T, Zang B (2015) Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-B) signaling pathway