GLP-1s are a class of medications originally used to treat type 2 diabetes
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Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M et al
doi: 10.1126/scitranslmed.aah6733 32 NomuraTMusialTFMarshallJJZhuYRemmersCLXuJet al
Our preliminary study showed that Akt-1 signaling pathway in this neurodevelopment model of schizophrenia was decreased and repeated co-treatment with MIR (but not escitalopram) and aripiprazole reversed this effect, especially in the frontal cortex (56)
The STEP 1 trial (Wilding et al., The Lancet, 2021) showed an average weight loss of 14.9% over 68 weeks versus 2.4% in the placebo group a landmark result that established semaglutide as the benchmark for GLP-1 weight loss