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A novel one conjugated to the hapten, keyhole limpet hemocyanin (KLH), tested in rodent models, was shown to decrease feeding and induce weight loss (178)

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Mechanistically, T4-overexpressing mice showed increased protein expression levels and phosphorylation of P38, ERK and AKT, whereas knockout mice had decreased levels of both expression and phosphorylation of these proteins

This dual capability positions melatonin as a robust non-enzymatic antioxidant, functioning both intra- and extracellularly [93]

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Published 2024 May 23