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In this context, persistent ROS accumulation can overwhelm antioxidant capacity and has been linked to caspase-dependent gasdermin cleavage in mammary cancer cells 186-189

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Month 12: Quarterly technical progress reports detailing technical progress made, tasks accomplished, major risks/mitigations, a technical plan for the remainder of Phase II Base Period (with necessary updates as in the parenthetical remark for Months 3, 5, and 7), planned activities, trip summaries, and any potential issues or problem areas that require the attention of the DARPA PM

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