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Romanelli RJ, Rosenblatt AS, Marcum ZA, Flatt JD
Research Characteristics: Tripeptidecopper complex studied for its role in cellular signaling and biological regulation Investigated for activity in collagen synthesis pathways and tissue remodeling Examined in laboratory research for effects on oxidative stress and inflammatory balance THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only
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The peptide has an arginine in place of glutamic acid at position 3, and an extra 13-amino-acid extension on the front (the N-terminus ), making the full chain 83 amino acids instead of native IGF-1's 70
Ethics declarations Ethics approval and consent to participate The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials (www.irct.ir) at 28/08/2021 (registration number: IRCT20200920048782N1)
