(4) Bock, Patricia M et al
Common names in the category include Ozempic and Wegovy
In my capacity as director of state government affairs for the American Diabetes Association (ADA), I represent the ADA in policy matters before the Ohio General Assembly
When you lose estrogen ovary removal, receptor deletion or bloc- this leads to weight gain and increased food motivated behavior Your body makes GLP-1
It also supports elastin production, which gives skin its ability to bounce back
Trial evidence: Tesamorelin 2mg SC daily sustained GH/IGF-1 elevation, 15-18% visceral fat reduction over 6 months (Falutz, NEJM 2007, PMID 17699044) Ipamorelin 200-300 mcg peak GH 5-10x baseline within 30 minutes, no cortisol/prolactin bump (Raun, EJE 1998, PMID 9539826) GHRH + GHRP synergy 2-3x greater amplitude than either alone (Bowers, JCEM 1991, PMID 2004615) Community protocols extend this evidence base with cycling patterns that weren't studied in the original trials the 5-on/2-off rhythm and 8-week cycles are empirical community consensus, not clinically validated
