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Based on evidence reviewed in Cristofori et al, SCFAs like butyrate enhance TGF-/Smad3 signaling in B cells, promoting IgA class switching while suppressing IgE production through HDAC inhibition and GATA3 downregulation (129)

During the development of the bioanalytical assays for therapeutic peptides, a number of key considerations to ensure success were highlighted: 1

Beyond the clinical manifestations, PD incurs heavy economic costs due to prolonged caregiving, disability, and lost productivity