Promotional value is best judged by longterm utility
Benefits Of Microdosing Tirzepatide Fewer Side Effects During Dose Escalation Slower titration reduces the intensity of gastrointestinal effects for many patients, which explains why clinicians experiment with smaller steps when early nausea threatens continuation
Therefore, effective neuroprotective therapies are continuously being pursued
Semaglutide and Tirzepatide in Patients with Heart Failure with Preserved Ejection Fraction JAMA DOI: /10.1001/jama.2025.14092
Overall, the introduction of the new obesity pharmacotherapies may shift the focus of the multidisciplinary team on nutrition support during the rapid WL phase and on behavioural changes aiming to support long-term weight maintenance, similar to what is the focus after bariatric surgery
Cardiovascular safety may be assessed either before or after authorisation, depending on the indication and the risk profile of the medicine this is determined on a case-by-case basis and is not universally required pre-authorisation, particularly for obesity indications