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What we do early (and why it works): Hydration plan (not just drink more, but a measurable daily target) Fiber strategy tailored to tolerance (some patients worsen with aggressive fiber early) Movementeven short daily walks help gut motility Clinician-guided use of magnesium or other supports when appropriate Sherman Oaksspecific insight: In the San Fernando Valley, we see constipation worsen quickly in patients who are busy, underhydrated, and spending time outdoors year-roundespecially when appetite drops and fluid intake drops with it
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The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)
Toxicology , 465 , 153055
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