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Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

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However, it has been found that derivatives of biguanide, Q48, and Q54, are two novel CLIC1 blockers that have higher anti-proliferative efficacy than metformin in vitro glioma stem cell 2D cultures and 3D spheres (99)

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These examples highlight hydrogen water's ability to provide immediate antioxidant protection in cellular regions that may be less accessible to or less protected by GR activity, creating a more comprehensive defense system when used alongside functional glutathione recycling