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Osmolality Tonicity Assessment Nasal sprays should be formulated as isotonic solutions (270330 mOsm/kg) to minimize irritation and damage to the nasal mucociliary clearance apparatus

These benefits appear to be related, in part, to enhanced recruitment of collateral circulation, which supports oxygen delivery to compromised cardiac tissue

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This severe depletion of GSH results in the synthesis of large amounts of -glutamylcysteine, which is increasingly converted to pyroglutamate when glycine is depleted, leading to metabolic acidosis

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