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Coexistence of diabetes and hypertension has been found to increase fibrosis burden in comparison to having either diabetes or hypertension alone (van Hoeven and Factor, 1990)

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[27] [28] Seek urgent medical attention if you develop severe pain in the upper right side of your abdomen, especially if accompanied by fever or yellowing of the skin or eyes

HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]