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Studies involving human test subjects have shown that TB-500 causes the up-regulation of Actin and promotes cell proliferation

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Despite the large number of criteria for the diagnosis of ME/CFS, it is still unclear which one is the most useful and validated

Thomas Gates, then McNeils medical director, shot off a memo to the chief executive of Johnson & Johnson, the president of McNeil and other top officials, laying out a detailed plan of action for diffusing media interest in the research and limiting the extent and duration of the coverage. Gates envisioned two possibilities: Low Level of Publicity (most probable scenario) and High Level of Publicity (worst case scenario). For the latter, Gates suggested a series of responses: a letter-writing campaign to medical societies, doctors, pharmacists and academics