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Both semaglutide and tirzepatide have been used as addon therapies to insulin in patients with T1D and obesity, producing additional HbA1c reductions of up to 0.54% and 0.68%, respectively [82, 83]

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NASH is a severe form of NAFLD involving steatohepatitis that is pathologically characterized by macrovesicular lipid deposition, ballooning degeneration of hepatocytes, infiltration of inflammatory cells, and perivenular or pericellular fibrosis around the central venous area (zone 3)

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