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In contrast, levels of free l-asparagine, l-histidine, methionine and l-proline in erythrocytes were found to be lower at week 8 in the test compared with the control study group (all P -values 0044 and maximum difference of 53 M) (online Supplementary Table 3b)

The results have prompted a clinical trial to determine whether the association reflects a true protective effect

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Vitamin E is a particularly important antioxidant vitamin to prioritise in the diet after a course of Roaccutane