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The most pronounced improvements were in patients with frequent constipation compared to those with frequent diarrhea

A study in healthy volunteers explored the vasodilatory and headache-inducing properties of GLP-1, revealing no significant differences in post-infusion headache between GLP-1 and placebo [30]

The best temperature for it is between 2C and 8C (36F to 46F)

6XOX: Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW

While tirzepatide has a comparable binding affinity for the GIP receptor, its affinity for the GLP-1 R is approximately fivefold weaker than that of native GLP-1

The studies on the benefits of microdosing are largely anecdotal