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5.1 Search strategy Literature was systematically searched in databases including PubMed and international clinical trial registries (Controlled-Trials.com and ClinicalTrials.gov) from their inception through December 2025

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For example, in estrogen metabolism and regulation, the primary forms of estrogen are converted to various metabolites

Several neurotransmitters (serotonin, noradrenaline, dopamine, and histamine), peptides (neuromedin U, urocortin, bombesin, amylin, galanin), hormones (thyroid hormone, growth hormone) and cytokines (ciliary neurotrophic factor) also play a role in modulating feeding behavior and energy expenditure [5-10]

Follow an antioxidant-rich diet, including fruits, vegetables, and vitamin supplements, to naturally boost glutathione levels in the body