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Overactivity of astroglial A 2A R induces extrasynaptic and postsynaptic mGluR1 and mGluR5 coupling to Gq protein (G protein subunit, which activates phospholipase and thereby increases diacylglycerol and inositol-triphosphate levels) by enhancing astroglial glutamate release, which can further increase intracellular calcium levels and lead to inhibition of D 2 R signaling in A 2A R-D 2 R and A 2A R-mGluR5 complexes (Figure 1) [37]

[Abstract]2023 Jun 6;42(1):142

The future of medicine lies not just in treating disease, but in understanding and supporting the intricate web of connections that make us whole

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The dysregulated expression of the LDL-cholesterol-dependent ATP binding cassette transporter 1 (ABCA1), similar to that seen in Niemann-Pick type C1, results in decreased levels of HDL-C (16)

pregnant women often receive IV thiamine if needed (e.g., for hyperemesis) without issue