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Each dose tier delivered roughly 3 additional percentage points of weight loss, representing a linear dose-response relationship that holds across the full tested range

Characteristics of included studies Among the included trials, 119 (45.4%) were randomized controlled trials (RCTs) and the majority (80.5%) focused on adult populations

These diurnal rhythm changes are also evident in at the level of cellular and organ metabolism ( Drug abuse related changes in metabolism would also have negative effects on various body systems due to increased cell damage, increased excitotoxicity, reduced energy production, and lowered antioxidant potential in cells

Side effects vary by individual and should be reported to the prescribing provider