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Supplementary Video 1 Partial unbinding and binding simulation of Ex4-l-Ala

Injection site reactions are a common side effect of GLP-1s like semaglutide or tirzepatide, affecting around 1% to 8% of people taking the medications

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Preclinical data strongly map these peptides to enhanced barrier function, mucosal proliferation, and local immunomodulation

Although the study primarily reports clinical outcomes, changes in specific biomarkers indirectly suggest potential mechanisms of action of GLP-1RAs

Are GLP-1 drugs safe