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Reyhan Westbrook Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, United States Contribution RW, Acquisition of data, Analysis and interpretation of data Competing interests The authors declare that no competing interests exist

Nat Rev Endocrinol 15(11):666682

Sleep Deprivation The body naturally replenishes glutathione during deep sleep , so a lack of quality sleep can reduce its levels over time

Excess alcohol and medications Regular alcohol intake and certain drugs force the liver to work harder, using up large amounts of glutathione to break down toxins, eventually lowering its available levels

P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration

Proven benefits include: Anti-ageing protects against free radical damage