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Male Sprague-Dawley rats were used for behavioral testing, with 24-month-old rats of mixed sex also included for aged rat models

Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

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