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17 Figure 12: PIONEER 6 trial design Source: Clinical Study Report
Stahling later noted in 1905 that secretin belonged to a previously unknown group of substances produced in one part of the body that get released into the blood to produce a specific response elsewhere
Disease severity was categorized as 1 or 2 according to the WHO clinical ordinal scale 19
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Other potential side effects include a risk of hypoglycemia (especially when used with other diabetes medications), pancreatitis, allergic reactions, renal impairment, and an increase in heart rate
& Asmus, K.-D
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