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Patients begin with 0.25 mg and ramp up to the FDA-approved dose of 2.4 mg over 20 weeks

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Archives of Pharmacal Research, 30(7), 834839.

The underlying cause of the disease stems from the destruction of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain [71]

& Cheon, D