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In studies in rats, saw palmetto extracts were shown to actively bind alpha(1)-adrenergic ( 1 -adrenergic) receptors, muscarinic acetylcholine receptors, and 1,4-dihydropyridine-sensitive calcium channels in the prostate and bladder

In addition, the level of lipoprotein lipase (LPL) was increased in numerous tissues such as skeletal muscle and adipose tissue

225 , 226 While uricosuric agents are generally well-tolerated, it is crucial to acknowledge that benzbromarone and probenecid may be associated with certain adverse effects

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doi: 10.1186/s12931-018-0846-4

J Pharmacol Exp Ther 273(2):637642 Cognato GP, Agostinho PM, Hockemeyer J, Mller CE, Souza DO, Cunha RA (2010) Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life