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Freezing reconstituted solutions is generally discouraged because it can lead to aggregation and loss of activity due to ice crystal formation, especially if the solution isn't specifically formulated with cryoprotectants

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Both can be used concurrently when prescribed under medical supervision, as neither directly blocks the other's mechanism of action

1 2 Toft-Nielsen MB, Madsbad S, Holst JJ (August 2001)

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Treatment of pigmented lesions of the oral mucosa associated with a systemic disorder is usually not required