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The active-controlled design adds methodological rigour over placebo-only Phase 2 trials

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Do not try to reinsert the needle if this happens

Front Physiol

These are not FDA-approved for weight loss and exist in a different regulatory category, but they represent options that some researchers explore as alternatives or adjuncts to tirzepatide

The evidence base for GLP-1 agonists in binge eating disorder remains preliminary, with most data coming from case reports, small case series, and secondary analyses rather than large randomized controlled trials specifically designed for BED