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One day after the in vivo LPS challenge, PBMC showed the same level of basal respiration, ATP production, proton leak, and maximal respiration like before the challenge, indicating unaffected basal activity of OXPHOS

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Long-term safety profiles in humans are unknown

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For example, mutations in the AR gene can lead to constitutive activation of the receptor, promoting cell survival and proliferation independently of androgen levels (56)