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These symptoms significantly impair quality of life and often emerge before the onset of motor deficits ( 5 Astaxanthin (AST) Carotenoids have long been recognized for their positive effects on individuals health, with some acting as precursors to vitamin A, essential for various biological functions, while others, known as non-provitamin A carotenoids, offer protective benefits such as defense against photodamage (Zuluaga et al., 2018)

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All four -ketoacid dehydrogenase complexes contain three enzymatic activities, namely E1, E2, and E3