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IGF-1 is a critical mediator of muscle hypertrophy through activation of mTOR signaling and enhanced protein synthesis. Glass, Nature Reviews Molecular Cell Biology In essence: HGH = upstream signal that initiates the process IGF-1 = downstream executor that builds and repairs tissue Benefits Comparison: IGF-1 vs HGH While HGH and IGF-1 both promote growth, recovery, and performance, they do so through different pathways and timelines