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142 Compared to our heterodimerization-based optoPLDs and optogenetic superPLDs, the LOVPLD exhibited a much lower background activity in its dark state, enabling its use in more sensitive settings, generation of stable cell lines, and studying of PA metabolism and signaling in a truly acute sense without undesired contributions from chronic background activity

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It plays a crucial role in the generation of glutathione, the body's master antioxidant, which protects delicate cellular structures from oxidative stress and free radical damage

334 To explore its potential in high-risk populations, the ongoing KARDIA-3 trial (NCT06272487) is enrolling cardiovascular high-risk patients or those with advanced chronic kidney disease who are taking 24 antihypertensive agents

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