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Janus kinase and signal transducer and activator of transcription inhibitors in type 1 diabetes and immune checkpointrelated diabetes: current status and future perspectives

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202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione