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In summary, monothiol mechanism (iii), as exemplified for roGFP2(S 2 ) in Fig

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However, the actions of H 2 S are strictly concentration-dependent, acting as a double-edged sword: at physiological levels it functions as a beneficial signaling molecule, whereas at high concentrations it becomes strongly cytotoxic by inhibiting cytochrome c oxidase (Complex IV) at the end of the mitochondrial respiratory chain, leading to energy depletion (Caro et al., 2011

To assess the sustainability of metabolic, cardiovascular, and neurocognitive outcomes, comprehensive and meticulously designed RCTs with prolonged follow-up periods are essential

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