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This could indicate that the medication has degraded or been exposed to improper conditions

For example, it may have a benefit for hypertension, but we also need to look at how not just the benefit of actual hypertension meds compares but also the adverse event profile

& Macdonald, T

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[5] Sites in the body [edit] Quantitatively, the smooth endoplasmic reticulum of the liver cell is the principal organ of drug metabolism, although every biological tissue has some ability to metabolize drugs

This is possibly related to the increased mitochondrial hydrogen peroxide (49)