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However, not all patients respond effectively to GLP-1R monoagonists, and higher doses aimed at increasing efficacy result in adverse gastrointestinal effects

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Figure 3 3.3 Socioeconomic and health system impact PD imposes a significant socioeconomic burden, including direct healthcare costs (e.g., medications, hospitalizations, and surgery) and indirect costs (e.g., lost income, caregiver absenteeism, and reduced productivity)

In general, diuretics lower blood pressure by initially decreasing cardiac output and reducing plasma and extracellular fluid volume