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This function positions ITIH4 as a potential backup protease inhibitor, especially significant in conditions where classical regulators (e.g., C1-inhibitor) are deficient or dysfunctional
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Most patients who experience thirst on tirzepatide find it manageable and temporary, particularly during the initial weeks of treatment or after dose escalation
Notably, greater dispersion was observed among ASD samples, suggesting increased inter-individual metabolic variability within the ASD group