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The release of insulin and glucagon is a negative feedback loop : when blood glucose is high, insulin is released, inhibiting the release of glucagon

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ChIP analysis confirmed that SYNCRIP specifically binds to the R2 region (-639 to -515) of the HK2 promoter (Figures 6B-D and S10E), suggesting that SYNCRIP functions as a transcriptional activator of HK2 expression

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