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Sestrin2 is a leucine sensor for the mTORC1 pathway

Pickart, L., J.M

This fragment particularly targets and regulates fat metabolism

It's useful context: retinol (a vitamin A derivative) speeds cell turnover and is one of the best-studied topical anti-agers, but it can irritate, and gentler alternatives like bakuchiol exist

They screened six differentially expressed ferroptosis-related genes (IL6, ANGPTL7, CDKN1A, AKR1C3, NOX4, and VLDLR) and constructed a random forest model based on these genes, which demonstrated strong diagnostic performance in the validation dataset, highlighting the close relationship between ferroptosis and immunity in atherosclerosis pathogenesis (61)

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