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This additional indication for Wegovy arose from a multinational clinical trial that found that semaglutide reduced the risk of major adverse cardiovascular events (MACE) by 20%

Many patients find the upfront cost lower than insurance copays or clinic-based programs, especially over 6-12 months of therapy

Metformin primarily addresses insulin resistance and hepatic glucose production, whilst semaglutide enhances insulin secretion, reduces appetite, and slows gastric emptying

Combined with flat monthly pricing starting at $129, HSA/FSA eligibility makes personalized GLP-1 therapy genuinely affordable for most patients

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You can read the paper here (open access in Social Science & Medicine): Co-authors: Mey Bahar Buyukbabani, Vilius Dranseika, Rebecca C