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Cagrilintide is a long-acting analog of amylin (islet amyloid polypeptide), a pancreatic hormone co-secreted with insulin that induces satiety

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PMID: 1972841

However, in pathological states associated with tinnitus and neurodegeneration, this translocation is impaired or the binding affinity of Nrf2 to ARE is diminished, resulting in insufficient upregulation of antioxidant enzymes (Scuto et al., 2020

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