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Most side effects get better over time as your body adjusts

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39 Cardiovascular outcome trials with tirzepatide are underway but real-world data suggest it may provide better cardiovascular outcomes in people aged over 40 with type 2 diabetes and established cardiovascular disease compared with GLP-1 receptor agonists

Men with diabetes experience erectile dysfunction at rates of 50-75%, driven by vascular damage, neuropathy, and hormonal changes that tirzepatide's metabolic benefits might address

[185] Patients may experience mood elevation, euphoria, irritability, anxiety, or depression during treatment