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This is the dose that produced the 24.2% body weight reduction in Phase 2 trials

Several studies support the anti-inflammatory effects of GLP-1 receptor agonists

Retatrutide would be the first triple-agonist (GLP-1 + GIP + glucagon) if approved

Are GLP-1 injections safe for long-term weight loss

Injection Procedure: Allow the pen to reach room temperature if refrigerated (15 to 30 minutes) Attach a new pen needle for each injection Prime the pen by dialing to the flow check symbol and pressing the dose button until a drop appears at the needle tip Dial to the prescribed dose Clean the injection site with an alcohol swab Pinch the skin at the abdomen, thigh, or upper arm Insert the needle at a 90-degree angle and press the dose button fully Hold the button for 6 seconds before withdrawing Do not rub the injection site Liraglutide can be injected at any time of day, independent of meals, though many users find that evening dosing reduces nausea interference with daytime eating

Later innovations like tirzepatide expanded on this by targeting two receptors (GLP-1 and GIP) to improve metabolic function