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The alanine at position 8, the residue immediately adjacent to the DPP-4 cleavage bond, is replaced by alpha-aminoisobutyric acid (Aib), a non-canonical, doubly methylated amino acid whose steric bulk blocks protease access [1]

Similar documentation requirements

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(Comparatively, the Celiac Disease Foundation estimates that around one in 141 people have celiac disease.) For health reasons and otherwise, gluten-free diets have been trending over the past few years, with an estimated 30 percent of Americans reporting a desire to cut out gluten in 2013

Laboratory investigations examine receptor affinity, ligand-binding kinetics, receptor activation, intracellular signaling dynamics, receptor trafficking, receptor internalization, and downstream molecular communication

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