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The mean A1C reduction from a baseline of 8.28% was -2.01% (5 mg), -2.24% (10 mg), and -2.30% (15 mg) with tirzepatide versus -1.86% with semaglutide 1 mg

Because of tissue damage, ALT and AST increased, and, typically, ALT will be raised to a greater extent than AST [25]

ITT includes all randomized participants exposed to at least one dose of trial product that have completed the visit at week 2

Clinical trials represent another access pathway for patients meeting eligibility criteria

However, there were no significant differences in the proportion of patients with PDC 80% at day 360 for semaglutide QW (44.7%) compared with dulaglutide (43.3%, p = 0.86) (Table 2)