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Multicomponent exercise not only improves physical fitnessincluding scores on the Short Physical Performance Battery (SPPB), a popular scale for measuring frailtybut also improves cognitive function after 24 months of exercise in older patients with diabetes and impaired lower-limb function [235]

Moreover, the administration of antibiotics to inhibit the growth of S

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Indeed, activation of GLP-1R in different brain regions reduces food intake 6 and we clearly show that the OB is among these brain areas, with the demonstration that GLP-1-driven OB output activity also modulates food intake in a DIO model

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& Molinari, C