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Surgery should be deferred when shedding remains active, weight or nutrition is unstable, the diagnosis is uncertain, inflammatory or scarring disease is active, donor miniaturization is diffuse, expectations are unrealistic, or the patient believes transplantation will stop future shedding

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194,195 The activated PI3K catalyzes the conversion of membrane phospholipid Phosphatidylinositol-4,5-bisphosphate (PIP2) into Phosphatidylinositol-3,4,5-trisphosphate (PIP3)

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