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Another recent study showed that lifelong muscle PGC1 overexpression increased muscle mass in male but not female mice and improved muscle fatigue at the expense of specific force (14)

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one cohort study found that it doubled the risk of sepsis and tuberculosis admissions (79)

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Methods Inclusion Criteria Patients aged 65 years or older visiting the geriatric outpatient clinic or admitted to the geriatric ward at Spaarne Gasthuis, Haarlem and Hoofddorp, Netherlands